The Union Ministry of Health and Family Welfare (MoHFW) has notified amendments to the Drugs Rules, 1945, expanding the QR code-based track-and-trace framework to cover all vaccines, antimicrobials, anti-cancer medicines and narcotic and psychotropic drugs by bringing them under Schedule H2. The move aims to curb counterfeit and substandard medicines and strengthen India's fight against antimicrobial resistance (AMR). This article explains the new notification, India's drug-regulation framework under the Drugs and Cosmetics Act, 1940, the meaning of various drug schedules, how QR-code traceability works, the law on spurious and substandard drugs, and the AMR connection.